To assess the fetal lung maturity for determining the time of delivery in high risk pregnancy, we obtained 113 samples of amniotic fluid from 105 high risk pregnancy women, and shake test, amniotic fluid absorbance at 650nm, and
Amniostat-FLM(AFLM)
were
performed for the screening test of the fetal lung maturity.
We in vestigated the diagnostic reliability of the fetal lung maturity test in 54 cases of good fetal lung maturity at birth, delivered within 72 hours after last amniocentesis and 4 cases of respiratory distress syndrome (RDS) at birth.
The sensitivity and predictive value of mature test were 100% in all screening test. The specificity and efficiency were 83.3%, 84.5% in shake test, 70.4%, 72.4%, in OD 400nm, 61.1%, 63.8% in OD 650nm, 70.4% in AFLM.
The predictive value of RDS was 30.5% in shake test, 20.0% in OD 40nm, 16.0% in OD 650nm, 20.0% in AFLM.
If a good fetal lung maturity is assigned as any one of two was positive in all screening test, AFLM and shake test showed 89.7% efficiency. If a good fetal lung maturity is assigned as any one of three was positive in all screening tests, and OD
400nm
or-AFLM, shake test, and OD 650nm.
Conclusively, the screening test of fetal lung maturity for determining the time of delivery in high risk pregnancy is more effective with multiple screening tests than single test. Further studies will be needed in the efficiency of other
screening
tests, comparison studies with lung profile and vaginal samples.
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